A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease

Proc West Pharmacol Soc. 1995:38:113-20.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / toxicity*
  • Animals
  • Creatine Kinase / antagonists & inhibitors
  • Electron Spin Resonance Spectroscopy
  • Free Radicals
  • Gerbillinae
  • Glutamate-Ammonia Ligase / antagonists & inhibitors
  • Humans
  • Hydroxylation
  • In Vitro Techniques
  • Lipid Peroxidation / drug effects
  • Male
  • Neurons / drug effects
  • Neurons / enzymology
  • Neurotoxins / toxicity*
  • Salicylates / metabolism
  • Spin Labels
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism

Substances

  • Amyloid beta-Peptides
  • Free Radicals
  • Neurotoxins
  • Salicylates
  • Spin Labels
  • Creatine Kinase
  • Glutamate-Ammonia Ligase