Following electroshock treatment of the rabbit, polysomes have been found to disaggregate in the liver and kidney to an extent comparable with disaggregation in the cerebral cortex. After a single electroconvulsive shock, the process of polysomal disaggregation in the former two organs reaches maximum values at 10 and 60 min, but returns to control values at intermediate times. In the cerebral cortex the shift to control values observed at 20 min is not statistically significant.