Inhibition of testosterone 5 alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor

Biochem Biophys Res Commun. 1980 Jul 16;95(1):273-80. doi: 10.1016/0006-291x(80)90735-4.
No abstract available

MeSH terms

  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism
  • Animals
  • Binding Sites
  • Kinetics
  • Male
  • Microsomes / enzymology
  • Pregnanes / pharmacology*
  • Pregnanolone / analogs & derivatives
  • Pregnanolone / metabolism
  • Pregnanolone / pharmacology*
  • Prostate / enzymology
  • Rats

Substances

  • Pregnanes
  • RMI 18341
  • Pregnanolone
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase