Antihypertensive ureidopiperidines

J Med Chem. 1980 Aug;23(8):857-61. doi: 10.1021/jm00182a009.

Abstract

The synthesis of a series of 1-aralkyl-4-ureidopiperidines is reported. These compounds are related to the benzamidopiperidines exemplified by indoramin. Some of the ureidopiperidines are more potent antihypertensive agents than their benzamidopiperidine counterparts. Two examples, 1-(2-thenoyl)-3-[1-[2-(3-indolyl)ethyl]piperid-4-yl]urea and 1-(2-thenoyl)-3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperid-4-yl]urea (19 and 58), emerged as the most potent antihypertensive agents in this series.

MeSH terms

  • Animals
  • Antihypertensive Agents / chemical synthesis*
  • Desoxycorticosterone
  • Hypertension / chemically induced
  • Hypertension / physiopathology
  • Hypertension, Renal / physiopathology
  • Piperidines / chemical synthesis*
  • Piperidines / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Antihypertensive Agents
  • Piperidines
  • Desoxycorticosterone