Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase

J Med Chem. 1980 Jul;23(7):713-5. doi: 10.1021/jm00181a001.
No abstract available

MeSH terms

  • Animals
  • Azepines / chemical synthesis*
  • Azepines / pharmacology
  • Cytidine Deaminase / antagonists & inhibitors*
  • Humans
  • Kidney / enzymology
  • Liver / enzymology
  • Mice
  • Molecular Conformation
  • Nucleoside Deaminases / antagonists & inhibitors*
  • Nucleosides / chemical synthesis*
  • Nucleosides / pharmacology
  • Structure-Activity Relationship

Substances

  • Azepines
  • Nucleosides
  • Nucleoside Deaminases
  • Cytidine Deaminase