The standard surgical technique for enucleation of an eye containing a malignant melanoma of the uvea elevates intraocular pressure markedly and may thereby disseminate tumor cells and cause death. It is possible to enucleate an eye bear a malignant melanoma of the choroid without elevating intraocular pressure to more than 27 mm/Hg by employing a manometric intraocular pressure regulating system and the adjustable cryo-ring. The value of this method of enucleation in diminishing tumor deaths remains unknown.