Abstract
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Aorta / drug effects
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Blood Vessels / drug effects*
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Blood Vessels / pathology
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Cholesterol / analogs & derivatives*
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Cholesterol / toxicity
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Epoxy Compounds / toxicity*
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Ethers, Cyclic / toxicity*
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Female
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Hydroxycholesterols / toxicity
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Lanosterol / analogs & derivatives
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Lanosterol / toxicity
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Male
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Necrosis
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Oxidation-Reduction
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Pulmonary Artery / drug effects
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Rabbits
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Structure-Activity Relationship
Substances
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Epoxy Compounds
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Ethers, Cyclic
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Hydroxycholesterols
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Lanosterol
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Cholesterol