Abstract
The relative activity of three bile acid binding polymers in increasing cholesterol biosynthesis in the rat from 14C-acetate was determined by measuring blood levels of 14C-cholesterol after intraperitoneally administered 14C-acetate. CAT-FLOC and 3,3-ionene were 4-5 times more active than cholestyramine in this study which correlated well with the results of hypocholesteremic testing in dogs.
MeSH terms
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Acetates / metabolism*
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Animals
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Bile Acids and Salts / metabolism*
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Cholesterol / biosynthesis*
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Cholestyramine Resin / pharmacology
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Polyethylenes*
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Polymers / pharmacology
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Quaternary Ammonium Compounds / pharmacology
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Rats
Substances
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Acetates
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Bile Acids and Salts
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Polyethylenes
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Polymers
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Quaternary Ammonium Compounds
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Cholestyramine Resin
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poly-N,N-dimethyl-N,N-diallylammonium chloride
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3,3-ionene
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Cholesterol