2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol

G E Stokker; R L Smith; E J Cragoe Jr; C T Ludden; H F Russo; C S Sweet; L S Watson

doi:10.1021/jm00133a024

2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol

J Med Chem. 1981 Jan;24(1):115-7. doi: 10.1021/jm00133a024.

Authors

G E Stokker, R L Smith, E J Cragoe Jr, C T Ludden, H F Russo, C S Sweet, L S Watson

PMID: 7205867
DOI: 10.1021/jm00133a024

Abstract

The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.

MeSH terms

Animals
Blood Pressure / drug effects
Chemical Phenomena
Chemistry
Diuretics / chemical synthesis*
Diuretics / pharmacology
Dogs
Electrolytes / urine
Hypertension / physiopathology
Iodopyridones / chemical synthesis*
Iodopyridones / pharmacology
Rats

Substances

Diuretics
Electrolytes
Iodopyridones
4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol