Abstract
We studied the actions of lisuride, a dopaminergic ergot derivative, in 20 parkinsonian patients. When the dose was increased gradually, most patients tolerated up to 5 mg daily. Clinical assessment and objective, computer-assisted evaluation revealed improvement in akinesia, rigidity and tremor. Adverse reactions were similar to those seen with levodopa and bromocriptine, but somnolence tended to occur more often with lisuride.
MeSH terms
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Adult
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Aged
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Bromocriptine / therapeutic use
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Double-Blind Method
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Ergolines / therapeutic use*
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Humans
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Lisuride / administration & dosage
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Lisuride / adverse effects
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Lisuride / pharmacology
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Lisuride / therapeutic use*
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Middle Aged
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Movement
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Parkinson Disease / drug therapy*
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Placebos
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Reaction Time
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Receptors, Serotonin / drug effects
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Sleep / drug effects
Substances
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Ergolines
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Placebos
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Receptors, Serotonin
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Bromocriptine
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Lisuride