Abstract
A high frequency of both rheumatoid arthritis (RA) and HLA-DR4 was found in a Chippewa Indian population. Multiple immunogenetic "variants" of HLA-DR4 were demonstrated, each showing a different response in mixed lymphocyte culture which corresponded to a serologic pattern of reactivity to a panel of non-DR4 B cell alloantisera. No DR4-bearing HLA haplotype or DR4 "variant" was common to subjects with RA, all of whom were DR4-positive. The implications are discussed.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Arthritis, Rheumatoid / epidemiology
-
Arthritis, Rheumatoid / genetics
-
Arthritis, Rheumatoid / immunology*
-
HLA Antigens / genetics
-
HLA-DR4 Antigen
-
Histocompatibility Antigens Class II / genetics
-
Histocompatibility Antigens Class II / immunology*
-
Humans
-
Indians, North American*
-
Pedigree
Substances
-
HLA Antigens
-
HLA-DR4 Antigen
-
Histocompatibility Antigens Class II