Abstract
The responses of rabbit pupils to graded doses of both adrenergic and cholinergic drugs after chemical sympathectomy with 6-hydroxydopamine have been examined. For comparison, similar data were obtained in rabbits treated chronically with the norepinephrine synthesis inhibitor, alpha-methyl-para-tyrosine. While quantitative differences were apparent, the effects of these 2 treatments were qualitatively similar. In both cases, a marked reduction in the responsiveness of the iris to cholinergic agonists accompanied the development of supersensitivity to adrenergic amines.
MeSH terms
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Administration, Topical
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Animals
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Carbachol / administration & dosage
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Drug Interactions
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Epinephrine / administration & dosage
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Hydroxydopamines / administration & dosage*
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Injections, Intraperitoneal
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Iris / drug effects
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Isoproterenol / administration & dosage
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Male
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Methyltyrosines / administration & dosage*
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Norepinephrine / administration & dosage
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Pilocarpine / administration & dosage
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Pupil / drug effects*
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Pupil / innervation
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Rabbits
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Sympathetic Nervous System / drug effects
Substances
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Hydroxydopamines
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Methyltyrosines
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Pilocarpine
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Carbachol
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Isoproterenol
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Norepinephrine
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Epinephrine