We have experienced a case of spontaneous spinal epidural hemorrhage associated with von Willebrand's disease. The patient was repeatedly attacked by bleeding of the urinary tract, intramuscular hemorrhage of the right thigh in spite of the administration of AHF. She had a complication of pneumonia and died on the 94th day of hospitalization. The autopsy revealed extensive spinal epidural hemorrhage from the lower part of the first cervical to the 11th thoracic vertebrae. Because of its rarity in previous literature, this case is presented.