Childhood acute lymphoblastic leukemia associated with an unusual 8;14 translocation

Cancer Genet Cytogenet. 1982 Aug;6(4):339-43. doi: 10.1016/0165-4608(82)90090-5.

Abstract

An 8;14 chromosome translocation with the break points t(8;14(q11;q32) is described in bone marrow cells of a patient with null cell terminal deoxynucleotidyl transferase (TdT)-positive acute lymphoblastic leukemia. The patient, who is dysmorphic and mentally retarded, ha a normal 46,XY constitutional chromosome karyotype. A review of the more usual cytogenetic findings in this type of leukemia and a comparison of B-cell lymphoproliferative cytogenetic associations are presented.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bone Marrow / physiopathology
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Chromosomes, Human, 13-15*
  • Chromosomes, Human, 6-12 and X*
  • DNA Nucleotidylexotransferase / genetics
  • Humans
  • Karyotyping
  • Leukemia, Lymphoid / genetics*
  • Male
  • Translocation, Genetic*

Substances

  • DNA Nucleotidylexotransferase