Autoradiographic investigation of proliferative responses in rat incisor pulp after vincristine administration

Scand J Dent Res. 1980 Apr;88(2):96-103. doi: 10.1111/j.1600-0722.1980.tb01200.x.

Abstract

-0.7 mg/kg VCR was given to nine rats in three experimental groups. Twenty-three hours after VCR injection the animals were injected with 3H-thymidine. The animals were sacrificed 24, 48 and 72 h after the VCR injection, and by comparison with nine control animals similarly injected with sodium chloride solution and nucleotide, it was shown that VCR causes a delayed migration of pulp cells from the proliferative pool and a small but distinct inhibition of the incisal growth of the incisors. The growth inhibition corresponded to the normal growth over a 24-h period in non-VCR-injected animals.

MeSH terms

  • Animals
  • Autoradiography
  • Cell Division / drug effects
  • Dental Pulp / cytology
  • Dental Pulp / drug effects*
  • Female
  • Incisor / cytology
  • Incisor / drug effects*
  • Odontoblasts / drug effects
  • Odontogenesis / drug effects
  • Rats
  • Thymidine
  • Time Factors
  • Tritium
  • Vincristine / administration & dosage
  • Vincristine / pharmacology*

Substances

  • Tritium
  • Vincristine
  • Thymidine