Abstract
Thirty patients with advanced metastatic colorectal adenocarcinoma were treated with alanosine at a dose of 160 mg/m2 daily for 5 days every 4 weeks. Sixteen patients had received no prior chemotherapy and 14 had been previously treated with one or more cytotoxic agents. No patient met the criteria for a complete or partial response. The major toxicity was stomatitis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenocarcinoma / drug therapy*
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Adult
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Aged
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Alanine / adverse effects
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Alanine / analogs & derivatives*
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Alanine / therapeutic use
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Antibiotics, Antineoplastic / adverse effects
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Antibiotics, Antineoplastic / therapeutic use*
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Colonic Neoplasms / drug therapy*
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Drug Evaluation
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Female
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Humans
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Male
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Middle Aged
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Nausea / chemically induced
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Rectal Neoplasms / drug therapy*
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Stomatitis / chemically induced
Substances
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Antibiotics, Antineoplastic
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alanosine
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Alanine