Abstract
Germfree rats biosynthetize cholic and beta-muricholic acids. The latter does not exist in humans. Germfree rats were given human fecal suspensions. These rats degraded cholic acid into deoxycholic acid but failed to metabolize beta-muricholic acid.
MeSH terms
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Animals
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Bacteria / metabolism*
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Biotransformation
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Cholic Acid
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Cholic Acids / metabolism*
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Chromatography, Gas
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Deoxycholic Acid / biosynthesis
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Digestive System / metabolism
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Digestive System / microbiology*
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Feces / microbiology*
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Female
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Germ-Free Life
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Humans
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Male
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Rats
Substances
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Cholic Acids
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Deoxycholic Acid
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muricholic acid
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hyodeoxycholic acid
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Cholic Acid