A methodology has been developed to assess potential hazards from low-level exposures to radioactive pollutants. Estimates of dose rates to reference organs from internal and external exposure pathways (inhalation of contaminated air, ingestion of contaminated food or water, immersion in contaminated air, and exposure to contaminated ground surfaces) are computed with contemporary dosimetric models. These dose rates are used in a life-table analysis to estimate the radiation-induced cancer deaths and resultant years of life lost in an exposed cohort of 100,000 persons, all simultaneously liveborn and subject to the same risks of dying from competing causes (including natural background radiation). Estimates of the potential health risk are tabulated for approx. 150 radionuclides for each of the exposure pathways; results are summarized in terms of the probability of premature radiation-induced death for a member of the cohort due to incremental radiation exposure, and the average number of years of life lost per incremental fatality. The estimates of radiation-induced mortality generated by these methods provide a useful means of quantifying radiation risk; however, these estimates may be subject to large uncertainties, and can be best interpreted as a measure of the relative degree of hazard associated with exposures to various radionuclides through several exposure pathways.