Activation of dormant genes in specialized cells

Science. 1984 Jun 1;224(4652):946-52. doi: 10.1126/science.6719127.

Abstract

In several experimental systems the genomic capacity in specialized cells can be assessed by examining the activation of dormant genes. Since some of these specialized cells can be induced to change cell phenotype, all cell specializations do not necessarily involve irreversible genetic changes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anura
  • Cell Differentiation*
  • Cell Fusion
  • Cell Transformation, Neoplastic / metabolism
  • Chickens
  • Chromatin / physiology
  • DNA / genetics
  • DNA / metabolism
  • Drosophila
  • Embryo, Mammalian / physiology
  • Embryo, Nonmammalian
  • Extremities / growth & development
  • Gene Expression Regulation*
  • Humans
  • Hybrid Cells
  • Iris / growth & development
  • Methylation
  • Mice
  • Nuclear Transfer Techniques
  • Phenotype
  • Rats
  • Xenopus

Substances

  • Chromatin
  • DNA