Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization

J Antibiot (Tokyo). 1983 Dec;36(12):1601-5. doi: 10.7164/antibiotics.36.1601.

Abstract

A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of these components are described.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkenes / isolation & purification
  • Antibiotics, Antineoplastic / isolation & purification*
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Polyenes
  • Pyrones
  • Spectrophotometry
  • Streptomyces / growth & development
  • Structure-Activity Relationship

Substances

  • Alkenes
  • Antibiotics, Antineoplastic
  • Polyenes
  • Pyrones
  • PD 113270
  • PD 113271
  • fostriecin