The sub-cutaneous injection of physostigmine (Eserine), an indirect para-sympatheticomimetic by reversible anticholinesterase activity, is capable of provoking ejaculation. The result is therefore identical to that obtained with a spinal injection of neostigmine (Prostigmine), which is only effective by spinal injection. In 6 patients with lesions at T12, L1 and L2, the subcutaneous injection of physostigmine was always effective. When this injection does not provoke any adverse reactions, it can be repeated at home without medical supervision. When this injection results in ejaculation, the erection is improved in 80% of cases and the sexual act is made easier. The usual dose is 2 mg of Eserine. One woman is currently pregnant from such an ejaculation. This method can therefore be proposed in the outpatient treatment of sterility in couples in whom the man is paraplegic, until its oral administration has been perfected.