Abstract
A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Brain Chemistry*
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Cats
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Caudate Nucleus / analysis
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Cerebellum / analysis
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Dogs
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Humans
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Putamen / analysis
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Quinuclidines / metabolism
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Quinuclidinyl Benzilate / metabolism
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Radioligand Assay
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Rats
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Receptors, Muscarinic / analysis*
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Receptors, Muscarinic / metabolism
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Tomography, Emission-Computed
Substances
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Quinuclidines
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Receptors, Muscarinic
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quinuclidinyl benzilate receptor
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Quinuclidinyl Benzilate
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3-quinuclidinyl-4-iodobenzilate