Staphylococcus aureus inhibits contact sensitivity to oxazolone by activating suppressor B cells in mice

Int Arch Allergy Appl Immunol. 1984;73(3):269-73. doi: 10.1159/000233480.

Abstract

Killed Staphylococcus aureus strain Cowan I cells inhibit contact sensitivity to oxazolone in mice, when given intravenously 24-72 h before sensitization. With transfer experiments it was found that the cells responsible for the suppression are antigen-specific, nylon-adherent, resistant to antitheta serum + C, and sensitive to anti-mouse Ig serum + C. These suppressor B cells bear anti-oxazolone immunoglobulins and appear to exert their suppressive activity by preventing the contact sensitizer from reaching the specific reactive T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / classification
  • B-Lymphocytes / immunology*
  • Dermatitis, Contact / immunology*
  • Female
  • Immune Tolerance*
  • Immunity, Cellular
  • Immunization, Passive
  • Lymph Nodes / cytology
  • Lymph Nodes / transplantation
  • Lymphocyte Activation*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Oxazolone / administration & dosage
  • Oxazolone / immunology
  • Staphylococcal Infections / immunology
  • Staphylococcal Vaccines / administration & dosage*
  • Staphylococcal Vaccines / immunology

Substances

  • Staphylococcal Vaccines
  • Oxazolone