Abstract
Killed Staphylococcus aureus strain Cowan I cells inhibit contact sensitivity to oxazolone in mice, when given intravenously 24-72 h before sensitization. With transfer experiments it was found that the cells responsible for the suppression are antigen-specific, nylon-adherent, resistant to antitheta serum + C, and sensitive to anti-mouse Ig serum + C. These suppressor B cells bear anti-oxazolone immunoglobulins and appear to exert their suppressive activity by preventing the contact sensitizer from reaching the specific reactive T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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B-Lymphocytes / classification
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B-Lymphocytes / immunology*
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Dermatitis, Contact / immunology*
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Female
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Immune Tolerance*
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Immunity, Cellular
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Immunization, Passive
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Lymph Nodes / cytology
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Lymph Nodes / transplantation
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Lymphocyte Activation*
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Male
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Mice
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Mice, Inbred C57BL
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Oxazolone / administration & dosage
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Oxazolone / immunology
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Staphylococcal Infections / immunology
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Staphylococcal Vaccines / administration & dosage*
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Staphylococcal Vaccines / immunology
Substances
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Staphylococcal Vaccines
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Oxazolone