Pre-B cell leukemia associated with chromosome translocation 1;19

Blood. 1984 Mar;63(3):721-4.

Abstract

Chromosome banding studies on 60 children with acute lymphocytic leukemia (ALL), including "null," pre-B, B, and T cell phenotypes, were performed. In 4 of 17 patients with pre-B cell ALL, we noted a previously undescribed chromosome translocation, t(1;19)(q23;q13). This translocation was not found in patients with "null" cell, B cell, or T cell ALL. Since each patient with the 1;19 translocation experienced early treatment failure, t(1;19)(q23;q13) may mark a subgroup of patients with pre-B cell ALL who have an especially poor prognosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology*
  • Child
  • Child, Preschool
  • Chromosomes, Human, 1-3
  • Chromosomes, Human, 19-20
  • Female
  • Humans
  • Leukemia, Lymphoid / genetics*
  • Leukemia, Lymphoid / immunology
  • Male
  • Preleukemia / genetics*
  • Translocation, Genetic*