Abstract
PGE1, PGE2, and PGF2alpha over a dose range of 1 to 50 microgram/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a beta-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinopenia induced by PGE1 and PGF2alpha but not that induced by PGE2.
MeSH terms
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Adrenalectomy
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Animals
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Eosinophils*
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Epinephrine / pharmacology
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Hypothalamus, Anterior / physiology
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Leukocyte Count*
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Leukopenia / physiopathology*
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Male
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Propranolol / pharmacology
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Prostaglandins / physiology*
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Prostaglandins E / pharmacology
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Prostaglandins F / pharmacology
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Rats
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Splenectomy*
Substances
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Prostaglandins
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Prostaglandins E
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Prostaglandins F
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Propranolol
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Epinephrine