Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid

Int J Clin Pharmacol Res. 1983;3(3):179-84.

Abstract

Ten surgical patients--4 males and 6 females, mean age: 46.7 years--affected by various pathological conditions were selected for this clinical trial. The patients were divided into two groups of 5 as follows: Group I on the third day received 10%. Intralipid (500 mg) + l-carnitine i.v. (100 mg/kg); on the sixth day 10% Intralipid (500 mg) infusion was given alone. Group II on the third day received 10% Intralipid (500 mg) infusion, and on the sixth day 10% Intralipid (500 mg) + l-carnitine (100 mg/kg). The laboratory parameters (cholesterol, triglycerides, HDL, LDL, VLDL, apolipoprotein A and B) showed that the lipids administered with l-carnitine were more rapidly metabolized than those without.

MeSH terms

  • Carnitine / pharmacology*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, VLDL
  • Energy Metabolism / drug effects
  • Fat Emulsions, Intravenous / pharmacology*
  • Fatty Acids / metabolism
  • Female
  • Humans
  • Infusions, Parenteral
  • Lipids / blood*
  • Lipoproteins, VLDL / blood
  • Male
  • Middle Aged
  • Time Factors
  • Triglycerides / blood

Substances

  • Cholesterol, HDL
  • Cholesterol, VLDL
  • Fat Emulsions, Intravenous
  • Fatty Acids
  • Lipids
  • Lipoproteins, VLDL
  • Triglycerides
  • Cholesterol
  • Carnitine