Nitrogen analogues of phencyclidine: 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines

Abstract

In order to investigate the effect of the introduction of a nitrogen atom in the alicyclic moiety of phencyclidine (PCP) a series of 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines were synthesized. The in vivo assays in mice and EEG in rabbits indicated that the presence of a second basic center in the molecule resulted in a loss of PCP-like activity. The new compounds were devoid of analgesic activity.