Abstract
Chromatography with a solid-phase polyelectrolyte based on ethylene maleic anhydride polyelectrolyte (EMA PE) has been shown to remove a large proportion of hepatitis B surface antigen (HBsAg), including hepatitis B virus (HBV) particles, from contaminated cryoprecipitate. This process may reduce the risk of transmission of HBV infection when factor VIII concentrates are administered.
MeSH terms
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Blood / microbiology*
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Blood Transfusion
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Chromatography
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DNA, Viral / analysis
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Factor VIII / isolation & purification*
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Hepatitis B / transmission
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Hepatitis B Surface Antigens / isolation & purification
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Hepatitis B virus / isolation & purification*
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Humans
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Polymers*
Substances
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DNA, Viral
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Hepatitis B Surface Antigens
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Polymers
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ethylene maleic anhydride polyelectrolyte
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Factor VIII