Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells

J Exp Med. 1983 Oct 1;158(4):1356-61. doi: 10.1084/jem.158.4.1356.

Abstract

Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells. The LAK activation factor was directly and consistently associated with IL-2 activity using classic protein purification techniques, adsorption to IL-2-dependent cell lines, and inhibition with anti-Tac antibody. As yet, no other cytokines have been found that perform the same role.

MeSH terms

  • Antibodies, Monoclonal / physiology
  • Binding, Competitive
  • Humans
  • Interleukin-2 / physiology*
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation*
  • Lymphocytes / classification
  • Lymphocytes / immunology
  • Phenotype
  • Receptors, Immunologic / immunology
  • Receptors, Interleukin-2
  • Stem Cells / immunology

Substances

  • Antibodies, Monoclonal
  • Interleukin-2
  • Receptors, Immunologic
  • Receptors, Interleukin-2