Abstract
Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Marrow / radiation effects
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Bone Marrow Transplantation*
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Cyclosporins / administration & dosage
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Cyclosporins / therapeutic use*
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Female
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Graft vs Host Disease / pathology
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Graft vs Host Disease / prevention & control*
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Rats
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Rats, Inbred Lew
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Spleen / cytology
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Spleen / transplantation
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Transplantation, Homologous
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Transplantation, Isogeneic