Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia

Blood. 1983 Mar;61(3):439-42.

Abstract

Of 33 patients who had undergone allogeneic bone marrow transplantation during first complete remission of acute nonlymphocytic leukemia, 21 patients have now been followed in continued complete remission for 6-64 mo (median greater than 18 mo) without maintenance chemotherapy. The median age of the surviving patients is 27 yr. Transplant-related complications occurring throughout the first year after marrow grafting were fatal in 7 patients, and leukemic recurrence led to the death of 5 patients. The actuarial long-term disease-free survival is 60% and the actuarial remission rate is 79%.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Marrow / drug effects
  • Bone Marrow / radiation effects
  • Bone Marrow Transplantation*
  • Cyclophosphamide / therapeutic use
  • Cytarabine / therapeutic use
  • Daunorubicin / therapeutic use
  • Humans
  • Leukemia / drug therapy
  • Leukemia / mortality
  • Leukemia / radiotherapy
  • Leukemia / therapy*
  • Patient Isolation
  • Whole-Body Irradiation

Substances

  • Cytarabine
  • Cyclophosphamide
  • Daunorubicin