Abstract
Human cellular Kirsten ras1 and ras2 genes were localized to chromosomes 6p23 ----q12 and 12p12 .05----pter, respectively, using human-rodent cell hybrids. Thus, the short arms of human chromosomes 11 (encoding lactate dehydrogenase-A and the proto-oncogene c-Ha- ras1 ) and 12 (encoding lactate dehydrogenase B and c-Ki- ras2 ) share at least two pairs of genes that probably evolved from common ancestral genes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromosome Mapping
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Chromosomes, Human, 13-15*
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Cricetinae
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Cricetulus
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DNA Restriction Enzymes
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Fibroblasts / physiology
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Genetic Linkage
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Humans
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Hybrid Cells / physiology
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Isoenzymes
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L-Lactate Dehydrogenase / genetics
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Mice
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Nucleic Acid Hybridization
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Oncogenes*
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Proto-Oncogene Mas
Substances
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Isoenzymes
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MAS1 protein, human
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Proto-Oncogene Mas
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L-Lactate Dehydrogenase
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DNA Restriction Enzymes