Abstract
In an Abelson-virus-transformed mouse lymphoid cell line with pre-B-cell characteristics, a few cells continuously produce heavy chains from both homologs. Each chain has a different variable region. These cells thereby exhibit allelic inclusion rather than allelic exclusion.
MeSH terms
-
Abelson murine leukemia virus / genetics*
-
Alleles*
-
Animals
-
B-Lymphocytes / immunology*
-
Cell Line
-
Cell Transformation, Neoplastic*
-
Fluorescent Antibody Technique
-
Hybridomas / immunology
-
Immunoglobulin lambda-Chains / genetics
-
Immunoglobulin mu-Chains / genetics
-
Leukemia Virus, Murine / genetics*
-
Mice
-
Nucleic Acid Hybridization
-
Plasmacytoma / immunology
Substances
-
Immunoglobulin lambda-Chains
-
Immunoglobulin mu-Chains