Abstract
Alteration of surface receptor of Ehrlich tumour cells by concanavalin A (Con A), shortwave UV and UV plus Con A have been studied. DNA of nuclear chromatins is highly sensitive to UV but receptor glycoprotein sites are UV resistant as evidenced by their retention of agglutination properties after radiation. Con A and UV plus Con A treatments of tumour cells delay the in vivo growth of solid tumour which may be due to some immunological mechanism.
MeSH terms
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Agglutination Tests
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Animals
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Carcinoma, Ehrlich Tumor / immunology
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Carcinoma, Ehrlich Tumor / pathology
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Carcinoma, Ehrlich Tumor / radiotherapy*
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Cells, Cultured
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Combined Modality Therapy
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Concanavalin A / pharmacology*
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Dose-Response Relationship, Radiation
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Male
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Mice
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Neoplasm Transplantation
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Platelet Glycoprotein GPIb-IX Complex*
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Platelet Membrane Glycoproteins*
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Receptors, Cell Surface / drug effects
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Receptors, Cell Surface / radiation effects*
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Ultraviolet Therapy*
Substances
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Platelet Glycoprotein GPIb-IX Complex
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Platelet Membrane Glycoproteins
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Receptors, Cell Surface
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glycoprotein receptor GPIb-IX
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Concanavalin A