Abstract
Sixty-five patients with small cell bronchogenic carcinoma were treated with intensive induction chemotherapy and supportive treatment. The clinical course of 43 patients who had pretreatment spirometry and arterial blood gases was studied. Thirteen patients developed pneumonia. Moderate hypoxemia, advanced age, and a low forced expiratory flow 25%-75% were associated with the development of pneumonia. Endobronchial obstruction and neutropenia, other factors associated with infection in cancer patients, appeared to be less important in this patient population.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age Factors
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow / drug effects
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Carcinoma, Bronchogenic / complications
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Carcinoma, Bronchogenic / drug therapy*
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Carcinoma, Bronchogenic / physiopathology
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Carcinoma, Small Cell / complications
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Carcinoma, Small Cell / drug therapy*
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Carcinoma, Small Cell / physiopathology
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Female
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Forced Expiratory Flow Rates
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Humans
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Lung Neoplasms / complications
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / physiopathology
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Male
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Middle Aged
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Oxygen / blood
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Pneumonia / etiology*
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Prognosis
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Regression Analysis
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Risk