Estimation of the single stranded region in the nuclear DNA of mouse tissues during aging with special reference to the brain

Arch Gerontol Geriatr. 1982 Sep;1(2):143-50. doi: 10.1016/0167-4943(82)90014-0.

Abstract

The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3% of the single stranded regions while that from younger animals contained 2%. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Animals
  • Brain / metabolism*
  • DNA, Single-Stranded / metabolism*
  • Endonucleases
  • Kidney / metabolism
  • Liver / metabolism
  • Male
  • Mice
  • Myocardium / metabolism
  • Single-Strand Specific DNA and RNA Endonucleases
  • Spleen / metabolism

Substances

  • DNA, Single-Stranded
  • Endonucleases
  • Single-Strand Specific DNA and RNA Endonucleases