Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells

J Biol Chem. 1978 Mar 10;253(5):1357-70.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • DNA, Neoplasm / biosynthesis*
  • Genes*
  • Genetic Variation
  • Kinetics
  • Methotrexate / pharmacology*
  • Nucleic Acid Hybridization
  • Polyribosomes / enzymology
  • RNA, Messenger / metabolism
  • Tetrahydrofolate Dehydrogenase / biosynthesis
  • Tetrahydrofolate Dehydrogenase / genetics*

Substances

  • DNA, Neoplasm
  • RNA, Messenger
  • Tetrahydrofolate Dehydrogenase
  • Methotrexate