Serial observations of angiotensin-converting enzyme and pulmonary function in sarcoidosis

Arch Intern Med. 1981 Jun;141(7):931-4.

Abstract

Fifty-six measurements of angiotensin-converting enzyme (ACE) level, diffusing capacity (DLCO), and total lung capacity (TLC) were made in 18 sarcoid patients with a maximum of 25 months of follow-up observation. During spontaneous or corticosteroid-induced changes in disease activity, there was a significant inverse correlation between changes in ACE level and changes in DLCO and between changes in ACE level and changes in TLC. These observations suggest that ACE measurement may be a useful adjunct to pulmonary function tests to follow the course of sarcoidosis and to monitor the effects of corticosteroid therapy on the lung.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Female
  • Follow-Up Studies
  • Humans
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A / blood*
  • Pulmonary Diffusing Capacity
  • Sarcoidosis / drug therapy
  • Sarcoidosis / enzymology
  • Sarcoidosis / physiopathology*
  • Total Lung Capacity

Substances

  • Adrenal Cortex Hormones
  • Peptidyl-Dipeptidase A