The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties

Biochem Biophys Res Commun. 1983 Dec 28;117(3):859-65. doi: 10.1016/0006-291x(83)91675-3.

Abstract

A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle. The primary structure of this atrial peptide is H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly- (sequence in text) Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH. The biological activity of this peptide is identical to that of atrial natriuretic factor and cardionatrin I isolated from rat atria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Animals
  • Atrial Natriuretic Factor
  • Chemical Phenomena
  • Chemistry
  • Diuretics / isolation & purification
  • Heart Atria / analysis*
  • Male
  • Natriuresis
  • Peptides / isolation & purification*
  • Rats
  • Rats, Inbred Strains

Substances

  • Amino Acids
  • Diuretics
  • Peptides
  • Atrial Natriuretic Factor