Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

J Biol Chem. 1982 Feb 25;257(4):1890-6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Transport
  • Carcinoma, Ehrlich Tumor / metabolism*
  • Chromatography, High Pressure Liquid
  • Folic Acid / analogs & derivatives*
  • Glutamates / pharmacology
  • Glutamic Acid
  • Glutamine / pharmacology
  • Kinetics
  • Male
  • Methotrexate / metabolism
  • Mice
  • Pteroylpolyglutamic Acids / metabolism*
  • Tetrahydrofolate Dehydrogenase / metabolism*

Substances

  • Glutamates
  • Pteroylpolyglutamic Acids
  • Glutamine
  • Glutamic Acid
  • Folic Acid
  • Tetrahydrofolate Dehydrogenase
  • Methotrexate