Cerebrospinal-fluid lymphocyte populations and immune complexes in active multiple sclerosis

Lancet. 1980 Aug 2;2(8188):229-32. doi: 10.1016/s0140-6736(80)90121-x.

Abstract

A specific subpopulation of mononuclear cells bearing a surface receptor for the Fc portion of IgG was considerably reduced in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation, but returned toward normal levels as the patient entered remission. Low concentrations of immune complexes were found in the CSF in nearly 50% of MS patients during exacerbations but immune complexes were not found in patients with stable MS.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adult
  • Antigen-Antibody Complex*
  • Cerebrospinal Fluid / immunology*
  • Cerebrospinal Fluid / metabolism
  • Female
  • Humans
  • Immunoglobulin Fc Fragments / cerebrospinal fluid*
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Remission, Spontaneous

Substances

  • Antigen-Antibody Complex
  • Immunoglobulin Fc Fragments