Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue

Gan. 1984 Sep;75(9):743-6.

Abstract

The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Carcinoma, Hepatocellular / analysis*
  • Child
  • Cloning, Molecular
  • DNA, Viral / analysis*
  • Genes, Viral
  • Hepatitis B virus / genetics*
  • Humans
  • Liver Neoplasms / analysis*
  • Male
  • RNA, Messenger / analysis

Substances

  • DNA, Viral
  • RNA, Messenger