Abstract
Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal / physiology
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Antigens, Surface / analysis*
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Antigens, Surface / immunology
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B-Lymphocytes / immunology*
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Binding, Competitive
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Fluorescent Antibody Technique
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Humans
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Interleukin-2 / metabolism
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Interleukin-2 / physiology
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Lymphocyte Activation*
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Staphylococcal Protein A / pharmacology
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Tumor Necrosis Factor Receptor Superfamily, Member 7
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Interleukin-2
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Staphylococcal Protein A
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Tumor Necrosis Factor Receptor Superfamily, Member 7