Influence of drugs and chemical upon hepatic enzymes and proteins-I. Structure-activity relationship between various barbiturates and microsomal enzyme induction in rat liver

Biochem Pharmacol. 1976 Mar 15;25(6):663-8. doi: 10.1016/0006-2952(76)90241-0.
No abstract available

MeSH terms

  • Aminopyrine N-Demethylase / metabolism
  • Aniline Hydroxylase / metabolism
  • Animals
  • Barbiturates / pharmacology*
  • Cytochrome P-450 Enzyme System / metabolism
  • Cytochromes / metabolism
  • Enzyme Induction / drug effects*
  • Glucuronosyltransferase / metabolism
  • Liver / anatomy & histology
  • Male
  • Microscopy, Electron
  • Microsomes, Liver / enzymology*
  • Microsomes, Liver / metabolism
  • Organ Size / drug effects
  • Phenobarbital / analogs & derivatives
  • Phenobarbital / pharmacology
  • Proteins / metabolism
  • Rats
  • Structure-Activity Relationship

Substances

  • Barbiturates
  • Cytochromes
  • Proteins
  • Cytochrome P-450 Enzyme System
  • Aniline Hydroxylase
  • Aminopyrine N-Demethylase
  • Glucuronosyltransferase
  • Phenobarbital