Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine

MeSH terms

• Animals
• Cephaloridine / adverse effects*
• Cephaloridine / metabolism
• Chemical and Drug Induced Liver Injury*
• Furans / adverse effects*
• Furans / metabolism
• Furosemide / adverse effects*
• Furosemide / metabolism
• In Vitro Techniques
• Kidney / pathology
• Kidney Diseases / chemically induced*
• Kidney Diseases / metabolism
• Liver / pathology
• Liver Diseases / metabolism
• Male
• Mice
• Microsomes / metabolism
• Necrosis
• Thiophenes / adverse effects*
• Thiophenes / metabolism