[Interaction of 3-[3H]-2-n-nonyl-4-hydroxy-quinoline-N-oxide with submitochondrial particles of beef heart. I. Inhibition of the respiratory activity]

P Riccio; S Passarella; S M Simone; E Quagliariello

[Interaction of 3-[3H]-2-n-nonyl-4-hydroxy-quinoline-N-oxide with submitochondrial particles of beef heart. I. Inhibition of the respiratory activity]

Boll Soc Ital Biol Sper. 1979 Dec 15;55(23):2406-11.

[Article in Italian]

Authors

P Riccio, S Passarella, S M Simone, E Quagliariello

PMID: 575765

Abstract

The inhibitory effect of 3-3H-2-n-nonyl-4-hydroxy-quinoline-N-oxide (3H-NQNO) on the respiration induced by NADH or by succinate was studied in submitochondrial particles from beef heart. Polarographic experiments showed that oxygen uptake by submitochondrial particles was inhibited by 3H-NQNO. Similar results were obtained with the unlabelled compound NQNO. The inhibitory activity of 3H-NQNO on the respiration was 2 or 3 times better than that of the heptyl derivatives (HQNO) and additive with that shown by antimycin.

Publication types

English Abstract

MeSH terms

Animals
Cattle
Hydroxyquinolines / pharmacology*
In Vitro Techniques
Mitochondria, Heart / drug effects*
Mitochondria, Heart / metabolism
Oxygen Consumption / drug effects
Subcellular Fractions / drug effects

Substances

Hydroxyquinolines