Corpora lutea were obtained from wallabies at different stages of pregnancy, following removal of pouch young to initiate embryonic development. Progesterone was present at a concentration of 11.3 ng/mg in quiescent corpora lutea from lactating animals. Progesterone values rose with increasing corpus luteum weight to reach a maximum of 40--50 ng/mg in corpora lutea weighing 50--60 mg. Total progesterone reached a maximum of 1500 +/- 300 (s.e.m.) ng at Days 21--23 after removal of pouch young, but fell markedly at Days 24 and 25 (900 +/- 150 ng) immediately before parturition.