Abstract
PIP:
The synthesis of a series of triphenylethlenes with CF(3) groups placed directly on the ethylene carbon is described, and the postcoital and uterotropic activities of these 1-trifluoromethyl-1,2,2-triphenylethylenes are determined. The parent compound and 3 substituted analogs were prepared by the stepwise replacement of the vinylic F atoms of hexafluoropropene with aryl groups from ArLi reagents. The postcoital antifertility and uterotrophic activities in the rat were determined by treating rats with induced precocious puberty with the synthesized compounds for 6 days after mating occurred. The most potent compound of this series was trans-p-methyoxy-alpha-phenyl-alpha'-(trifluoromethyl) stilbene.
MeSH terms
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Administration, Oral
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Animals
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Benzyl Compounds / administration & dosage
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Benzyl Compounds / chemical synthesis
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Benzyl Compounds / pharmacology
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Contraceptives, Oral / administration & dosage
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Contraceptives, Oral / chemical synthesis*
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Contraceptives, Oral / pharmacology
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Contraceptives, Postcoital / chemical synthesis
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Ethylenes / administration & dosage
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Ethylenes / chemical synthesis*
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Ethylenes / pharmacology
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Female
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Fertility / drug effects
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Fluorine
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Magnetic Resonance Spectroscopy
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Male
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Rats
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Rats, Inbred Strains
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Structure-Activity Relationship
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Styrenes / administration & dosage
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Styrenes / chemical synthesis
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Styrenes / pharmacology
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Time Factors
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Uterus / drug effects
Substances
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Benzyl Compounds
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Contraceptives, Oral
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Contraceptives, Postcoital
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Ethylenes
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Styrenes
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Fluorine