In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs

Eur J Pharmacol. 1979 Dec 20;60(4):391-2. doi: 10.1016/0014-2999(79)90250-4.
No abstract available

MeSH terms

  • Aminopyridines*
  • Animals
  • Antidepressive Agents, Tricyclic / pharmacology
  • Antipsychotic Agents / pharmacology
  • Cerebral Cortex / metabolism
  • Hypnotics and Sedatives*
  • Mice
  • Psychotropic Drugs / pharmacology*
  • Pyrilamine*
  • Receptors, Histamine / metabolism*
  • Receptors, Histamine H1 / metabolism*

Substances

  • Aminopyridines
  • Antidepressive Agents, Tricyclic
  • Antipsychotic Agents
  • Hypnotics and Sedatives
  • Psychotropic Drugs
  • Receptors, Histamine
  • Receptors, Histamine H1
  • Pyrilamine