Abstract
PIP:
Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostaglandin E1 (PGE1) also inhibits platelet aggregation and stimulates cyclic AMP synthesis by stimulation of adenyl cyclose. Caffeine, on the other hand, inhibits platelet phosphodiesterase, and increases cyclic AMP levels. PGA1 and PGF1 alpha can also inhibit platelet aggregation but only at very high concentrations.
MeSH terms
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Adenine Nucleotides / biosynthesis
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Adenine Nucleotides / pharmacology*
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Adenosine Triphosphate / metabolism
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Adenylyl Cyclases / blood
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Adenylyl Cyclases / metabolism
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Blood Coagulation / drug effects
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Blood Platelets* / enzymology
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Blood Platelets* / metabolism
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Butyrates
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Caffeine / pharmacology
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Carbon Isotopes
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Centrifugation
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Cyclic AMP / biosynthesis
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Cyclic AMP / pharmacology
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Depression, Chemical
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Drug Synergism
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Humans
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Imidazoles / pharmacology
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Phosphoric Monoester Hydrolases / antagonists & inhibitors
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Phosphoric Monoester Hydrolases / metabolism
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Platelet Adhesiveness / drug effects
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Prostaglandins / pharmacology*
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Stimulation, Chemical
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Tritium
Substances
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Adenine Nucleotides
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Butyrates
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Carbon Isotopes
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Imidazoles
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Prostaglandins
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Tritium
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Caffeine
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Adenosine Triphosphate
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Cyclic AMP
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Phosphoric Monoester Hydrolases
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Adenylyl Cyclases